Kate Tarleton grows up on a Southern plantation and becomes engaged to her guardian, Dr. Robert Manning, a famous surgeon. When Robert, Kate, and her younger sister Mary Lou visit New York, where the doctor wishes to conduct medical experiments, the superstitious Kate goes to the home of a fortune-teller named Stella Hill. Stella, whose principal business is white slave trafficking, drugs Kate and forces her to work in a "den of vice," run by Stella and her accomplice Jimmy Bristol, where she contracts syphilis and goes insane. Robert, Detective Ellis, and a lawyer named Billy Meredith rescue Kate, who recovers her sanity but remembers nothing of her bondage.

Cast

Alice Brady

Kate Tarleton

Frank Morgan

Dr. Robert Manning

Crauford Kent

Billy Meredith

Alice Hollister

Stella Hill

Johnnie Walker

Hampton Gray

Anne Cornwall

Helen Lackaye

Louise Meredith

Paul Doucet

Jimmy Bristol

Frank Evans

Detective Ellis

Myra Brooks